(Weimer, 1982, quoted by Guidano, 1991.) Pp. 21-22) the fact that humans are, firstly, agencies and that, as such, we belong to the order of the primates, joined the already identified important role that plays in our discussions the problem of knowledge inevitably leads to the acceptance of an evolutionary epistemological perspective (Popper & Eccles, 1977;) Guidano 1987,1990,1991,1993; Miro, 1994; Balbi, 1994) by which knowledge is reputed a property of life itself rather than an exclusive property of we human beings. Thus, knowledge being a function of organisms, evolves with these and, therefore, can be studied and explained by a scientific discipline that study the evolution of knowledge in multiple knowledge systems. Jane Pan: the source for more info. Of this mode, the knowledge is taken in the domain of philosophy to the domain of science. Focus posracionalista if agencies are, as he said Maturana, closed systems (Maturana & Varela, 1984;) Maturana, 1993 b), i.e. systems determined in our structure, is this that determines and not the means – both internal changes and the possible interactions with the latter occurring us. So that everyone knows as its own structural determinations. Accordingly, I accept as valid the claim that we do not have access to the knowledge of an objective reality and knowledge, rather than a representation corresponding to a supposed univocal order of reality, is an internal order, giving each agency, according to its own structure, to the accumulation of internal disturbances which are fired inside not as a result of their interactions with the environment. To say that knowledge is self-organization of the own experience and is, therefore, an indication of the structure of the Agency who knows and not of the supposedly known reality. This fact derives no less significant for the purposes of the problem that concerns us that: being human knowledge self-organization of the experience itself can be considered as, to this, not only cognitive (in intellective sense) but also composed of emotional aspects that are knowledge in the strictest sense of the term.